SORTILIN

SORTILIN: many headed hydra.

Sortilin and atherosclerosis

The complexity and intricacy of nature has recently been illustrated with the role of sortilin in atherosclerosis. Sortilin, a VPS10p sorting receptor initially identified in human brain tissue, suddenly gained much attention from the cardiovascular community as unbiased genome-wide association studies (GWASs) repeatedly demonstrated that single nucleotide polymorphisms (SNPs) at the 1p13.3 loc...

Sorting out sortilin.

G association studies have the potential to lead to identification of novel pathways and mechanisms for the pathogenesis of common complex diseases. Previous genome-wide association studies have identified a locus on 1p13 as a risk locus for dyslipidemia and myocardial infarction. However, the responsible mechanisms have remained elusive. Two recent reports implicate SORT1 as the causative gene...

Pro-neurotrophins, sortilin, and nociception

Nerve growth factor (NGF) signaling is important in the development and functional maintenance of nociceptors, but it also plays a central role in initiating and sustaining heat and mechanical hyperalgesia following inflammation. NGF signaling in pain has traditionally been thought of as primarily engaging the classic high-affinity receptor tyrosine kinase receptor TrkA to initiate sensitizatio...

Sortilin and the risk of cardiovascular disease.

Plasma low-density lipoprotein cholesterol (LDL-C) levels are a key determinant of the risk of cardiovascular disease, which is why many studies have attempted to elucidate the pathways that regulate its metabolism. Novel latest-generation sequencing techniques have identified a strong association between the 1p13 locus and the risk of cardiovascular disease caused by changes in plasma LDL-C le...